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KMID : 0378019770200080094
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New Medical Journal
1977 Volume.20 No. 8 p.94 ~ p.102
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A Clinical Study of Clobazam
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金聖權/Kim, Suhnggwon
朴正植/李重根/高昌舜/Park, Jung Sik/Lee, Joong Keun/Koh, Chang-Soon
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Abstract
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A double blind study and 12 weeks follow-up of Clobazam were performed . from October 1976 to May 1977 in Seoul National University Hospital.
They were 34 neurotic and 32 psychosomatic disorder patients. The results were followings.
1. Clobazam was more effective than placebo in both neurotic symptoms and psychosomatic
symptoms, especially in anxiety, inner restlessness, depression, cardiovascular symptom, respiratory symptom and gastrointestinal symptoms.
2. There were neither difference in each disease of neurosis nor psychosomatic disorder.
3. In each disease there were neither specific change in 12 weeks follow-up period nor no drug dependence is noted after 12 weeks follow-up.
4. There were mild side effects such as fatigability, dry mouth, mild ataxia and mild impotence. but these were not clinically important.
These results suggest that Clobazam is a good antianxiety drug in neurosis and psychosomatic disorder in OPD clinic. There are neither clinical significant side effect nor drug dependence.
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KEYWORD
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